Naloxone is an opioid receptor antagonist that reverses overdose effects by blocking brain opioid receptors. It is administered by injection or nasal spray, with the injectable form used by medical professionals and the nasal spray for non-medical personnel. It is crucial due to the opioid epidemic and is carried by emergency services and individuals at risk.
How Does Naloxone Work?
Naloxone acts as an “Antagonist”. It rushes straight to the brain where the opioids are bound and works by blocking the connection altogether by eliminating the opioids from the receptor.
The effects of Naloxone hydrochloride are rapid as it starts working within a fraction of a second. Naloxone blocks the opioid receptors and lasts from 30 to 90 minutes.
A single dose of Naloxone could be enough to reverse an overdose. Multiple doses are needed in case of extremely potent opioids.
Naxolone hydrochloride is available in two forms: Injection and Nasal spray
Injection- professional training required
Auto-Injectable – an auto-injection device that is convenient in emergency cases. It could be injected by family members or emergency personnel.
Nasal spray – Narcan nasal spray, a pre-filled needle-free device could be sprayed into one nostril while the patient lies on the back. It requires no assembly, as it is designed to access in emergency cases.
Naloxone comes in different brands with different dosages. Its potentiality may vary so the same product wouldn’t be effective for all.
Since Narcan is a nasal spray, the average dose is meant to be one spray in a nostril. Each bottle of Narcan contains one dosage (one spray) of Naloxone. If the person doesn’t respond within 2 to 3 minutes of the first dose, spray the second dosage without further delay. Continue the process for 2 to 3 minutes until the person responds.
Consult with your doctor in case you would like to know which Narcan product would be the best for you.
Once the symptoms of the opioid are identified, follow the steps below to use naloxone
After Narcan is given move the person to their side and call for emergency medical help right away.
Since it is an FDA-approved medication it is safe to use. Remember that Naloxone is opioid specific medication, so there is no cause for concern.
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